Interspecific comparisons reveal remarkable diversity in patterns of gene expression, even among closely related species. Combinatorial regulatory mechanisms could facilitate the evolution of this diversity. However, the high degree of interdependence characteristic of combinatorial networks would represent a major constraint on evolution and might generate many features that have no direct adaptive value.

Op basis van de zgn. wijsbegeerte der wetsidee van Dooyeweerd (1894-1977) bouwt de auteur een christelijke, wijsgerige antropologie.

Investigation of the use of intervention data in estimating parameters in a Bayesian network.

Constans, who defends the unanimous reading of the manuscripts, explains ‘tertium’ as a reference to two previous senatus consulta which Fufius did not veto . The problem with this interpretation is that Fufius is not even mentioned in the passage Constans cites; in fact, this letter marks Fufius' first appearance in the correspondence. On the basis of what is preserved it is difficult to see how Atticus could have divined such a meaning in Cicero's ‘tertium’. Scholars have preferred to emend. (...) The proposals of Graevius and Manutius have been criticized by Shackleton Bailey on the grounds that ‘concessit’ cannot mean ‘non intercessit’ in the absence of any mention of previous intercessory action on Fufius' part. However, in view of Cicero's description of the tribune in ad Att. 1.14.1, Atticus would have been no less puzzled if Fufius' failure to veto went unexplained. No earlier allusion to Fufius is necessary. Both ‘territus’ and ‘tum’ provide an explanatory context for Fufius' behaviour which makes the word play in ‘concessit’ understandable and perfectly acceptable. Shackleton Bailey's own suggestion does not suit the context of the letter, as Ph. Moreau demonstrates in some detail. In addition to the arguments adduced by Moreau, it is important to notice that Shackleton Bailey's reading fails to conform to the confident and victorious mood of the letter or to the plot of the relevant paragraph : once Cato's intrusion has focused the resentment of the Senate against Clodius' supporters and his tactics, Cicero depicts Clodhis 'position as increasingly abject. (shrink)

It is sufficiently probable that quantitative scansion in Latin, imposed on a language in which accentuation by stress was alone significant originally, not only gave way to the earlier principle in the decline of Latin literature, but scarcely tended to suppress it at any time in common speech and in familiar writing. It is also probable therefore that even in literature dominated by quantity stress-accentuation was not obliterated altogether. In fact the incidences of it, in Vergilian verse at least, seemed (...) so characteristic that in late Antiquity the Vergilian stress-rhythms were apparently copied without any knowledge of the prosody of the hexameter. In modern expositions, the variety of Vergil's rhythms is generally referred, not only to scansion, but also to stress-accentuation: and it has recently been shown that lines in which stress and metrical ictus predominantly coincide are different in quality and expressiveness from lines in which they do not. Since however no general explanation or definition of this difference in quality seemed to have been offered, I lately attempted a simple theory which would account for the different aesthetic values of lines of these two classes, and which would define, if possible, what these different values are. (shrink)

Quomodo versus lyrici legendi sint, plerumque inter metricos constat, licet de origine singulorum versuum vel colorum dubia moveantur; at ne illud quidem confirmari potest in genere illo peculiari, quo multae strophae Pindari et Bacchylidis et nonnullae poétarum scenicorum compositae sunt. Quod in talibus versibus maxime conspicuum est, hoc est, quod metra τоû σоυ et διπλασíоυ γéνоυς; in eis coniunguntur vel coniungi videntur, ita, ut ambitus utriusque partis aut par aut non multum maior minorve sit. lam antiqui metrici parum compertum habebant, (...) qua ratione eiusmodi versus explicarent. Cum maior pars ceterorum versuum lyricorum etiam post Alexandri aetatem in usu essent et doctrina grammaticorum hanc quoque materiam complecteretur, pauca versuum illorum vestigia remanebant, postquam chori lyrici et dramatici conticuerunt. Habemus quidem Meliambos Cercidae eodem genere carmina pangere conati, quo clarissimi illi veteres, sed eos perlegentes statim sentimus artem intermortuam non ab isto Megalopolitano nova vita donatam esse; nihil enim frigidius cogitari potest, quam si quis oda pindarica recitata ad Cercidae versus se convertat eosque alta voce pronuntiare conetur. Metrici graeci et romani praeter paucos versus eosque singillatim genus nostrum non tractant nee quisquam ex eorum numero de genere toto disseruit. Horatium et suamet ipsum arte prae ceteris excellentem et doctrina metrica haud mediocriter imbutum non aliter ac nos huius aevi philologos nescire, quomodo carmina pindarica ab ipso poeta componerentur, ex Oda notissima patet, in qua Pindarum quisquis studet aemulari frustra in re desperata desudare perhibetur. Ad universam lyricorum graecorum artem pertinent, quae a Cicerone in Oratore affirmantur, qui tamen clausulis orationis numerosae operam dans rem metricam non neglexit: sed in versibus res est apertior, quamquam etiam a modis quibusdam cantu remoto soluta esse videatur oratio, maximeque id in optima quoque eorum poëtarum, qui λυρικоí a graecis nominantur, quos, cum cantu spoliaveris, nuda paene remanet oratio. Causam hanc vel maximam esse puto in nullo alio carmina pangendi genere musicam, saltationem, metrum tam arte cohaesisse; cum poësis non iam pars habebatur υθμιξου, quod φθγγοδ, σχμα, συλλαβ definiebant, ut Aristoxeni terminis utar , via stabilita ambitum singulorum versuum ac colorum statuere conarentur et indoloem pedum metricorum conicendo indicarent. (shrink)

Published here in paperback for the first time is much of a final and long-anticipated work by R. G. Collingwood on philosophy of history, of which subject he was the greatest exponent in the English language. The original text of this work was only recently discovered. It is accompanied by shorter unpublished writings by Collingwood on historical knowledge and inquiry. A lengthy editorial introduction sets these writings in their context, and discusses philosophical questions to which they give rise.